Archive for February, 2009

Determination of entrapment efficiency and drug phase distribution of submicron emulsions loaded silybin

Abstract: This paper compared the performance of ultrafiltration (UF), ultracentrifugation (UC) and microdialysis (MD) for determining the entrapment efficiency (EE) of submicron emulsions (SE) loaded with a model drug, silybin (SB). Also, a novel way was created to evaluate the drug phase distribution of SE. The EE of SEI, SEII and SEIII with a range of […]

Evaluation of albumin microspheres as oral delivery system for Mycobacterium tuberculosis vaccines

Abstract: Mucosal immunization has been suggested to be the best option for preventing Mycobacterium tuberculosis infection. The purpose of this study was to develop albumin microspheres containing Mycobacterium tuberculosis antigens and to determine if oral administration of the microspheres can induce antigen-specific mucosal and systemic immune responses. Albumin microspheres containingMycobacterium tuberculosis dead cells and cell lysate were prepared. The physico-chemical characteristics […]

Formulation, characterization and evaluation of rotavirus encapsulated PLA and PLGA particles for oral vaccination

Abstract: Polylactide (PLA) and polylactide-co-glycolide (PLGA) particles entrapping rotavirus (strain SA11) were formulated using a solvent evaporation technique. To minimize denaturation of viral antigen during the emulsification process, serum albumin was used as a stabilizer. Use of NaHCO3 and sucrose during the primary emulsification step resulted in uniform stabilized particles entrapping rotavirus. Sonication during the primary emulsion […]

Effect of alginate-pectin composition on drug release characteristics of microcapsules

Abstract: Microencapsulation of model drug, acetylsalicylic acid into bio-based polymer, alginate-pectin matrix has been undertaken in this work to characterize the microcapsules based on their composition. Different proportions of the alginate-pectin solutions prepared with drug were homogenized and atomized using nitrogen gas into 1.0 M calcium chloride solution to form sol-gel microcapsules. Drug loaded microcapsules were […]

Effects of encapsulated rabbit mesenchymal stem cells on ex vivo expansion of human umbilical cord blood hematopoietic stem/progenitor cells

Abstract: The expansion of umbilical cord blood mononuclear cells (UCB MNCs) was investigated in a novel co-culture system by means of encapsulation of rabbit bone marrow (BM) mesenchymal stem cells (MSCs) in alginate beads (Alg beads). Three kinds of media were applied and the experiments lasted for 7 days. The total nucleated cell density was measured […]

Development of a novel nanocapsule formulation by emulsion-diffusion combined with high hydrostatic pressure

Abstract: A common method used to prepare polymeric nanoparticles in pharmaceutical technology is emulsion-diffusion. However, this method has several disadvantages due to the long duration of the process. At the diffusion step of conventional emulsion-diffusion, high pressure treatment could replace the addition of great quantities of water resulting in diffusion of the solvents from the internal […]

Retained integrity of protein encapsulated in spray-dried chitosan microparticles

Abstract: Chitosan microparticles for delivery of proteins were prepared by spray-drying technique. The effects of formulation (molecular weight and concentration of chitosan) and process variables (inlet drying air temperature and spray rate) on size and morphology of microparticles were characterized. Size of microparticles was mainly controlled by formulation variables, while particle morphology was influenced by both […]

Multilayer capsules: a promising microencapsulation system for transplantation of pancreatic islets

Abstract: In 1980, Lim and Sun introduced a microcapsule coated with an alginate/polylysine complex for encapsulation of pancreatic islets. Characteristic to this type of capsule is, that it consists of a plain membrane which is formed during a single procedural step. With such a simple process it is difficult to obtain instantly a membrane optimized with […]

Preparation of polysulfone microcapsules containing 1-octanol for the recovery of caprolactam

Abstract: Polysulphone (PSF) microcapsules containing 1-octanol were prepared with solvent extraction method for the recovery of caprolactam. One-step and two-step processes were, respectively, applied to prepare microcapsules. In order to get high extractant loading, a loading method with the assistance of ultrasound has been developed. With the two-step preparation process the extractant loss can be avoided. […]

Ascorbic acid retaining using a new calcium alginate-Capsul based edible film

Abrstract: This work aimed to produce a new calcium alginate-Capsul edible film with antioxidant incorporated in matrix. The vitaminic stability was evaluated in the films during their storage under different conditions for 140 days. The films were characterized with respect to their mechanical properties and surface morphology. The results indicated a 25.6% of vitamin C incorporation […]