Evaluation of albumin microspheres as oral delivery system for Mycobacterium tuberculosis vaccines
Abstract: Mucosal immunization has been suggested to be the best option for preventing Mycobacterium tuberculosis infection. The purpose of this study was to develop albumin microspheres containing Mycobacterium tuberculosis antigens and to determine if oral administration of the microspheres can induce antigen-specific mucosal and systemic immune responses. Albumin microspheres containingMycobacterium tuberculosis dead cells and cell lysate were prepared. The physico-chemical characteristics [...]